Synfacts 2010(4): 0445-0445  
DOI: 10.1055/s-0029-1219623
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Direct Mannich-Type Reaction Catalyzed by Chiral Lithium Complexes

Contributor(s): Hisashi Yamamoto, Zhi Li
M. Hatano, T. Horibe, K. Ishihara*
Nagoya University, Japan and CREST, Japan Science and Technology Agency, Nagoya, Japan
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22. März 2010 (online)


Chiral lithium complexes are relatively less represented in asymmetric catalysis, ­although they are rather simple compounds. This paper described a highly stereoselective chiral lithium binaphtholate catalyzed Mannich-type ­reaction between various aromatic aldimines and 1,3-dicarbonyl compounds. It’s also a very efficient way to construct consecutive stereocenters in high stereoselectivities.