Asymmetric Direct Mannich-Type Reaction Catalyzed by Chiral Lithium Complexes
M. Hatano, T. Horibe, K. Ishihara*
Nagoya University, Japan and CREST, Japan Science and Technology Agency, Nagoya, Japan
22 March 2010 (online)
Chiral lithium complexes are relatively less represented in asymmetric catalysis, although they are rather simple compounds. This paper described a highly stereoselective chiral lithium binaphtholate catalyzed Mannich-type reaction between various aromatic aldimines and 1,3-dicarbonyl compounds. It’s also a very efficient way to construct consecutive stereocenters in high stereoselectivities.