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Synfacts 2010(4): 0445-0445
DOI: 10.1055/s-0029-1219623
DOI: 10.1055/s-0029-1219623
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Direct Mannich-Type Reaction Catalyzed by Chiral Lithium Complexes
M. Hatano, T. Horibe, K. Ishihara*
Nagoya University, Japan and CREST, Japan Science and Technology Agency, Nagoya, Japan
Further Information
Publication History
Publication Date:
22 March 2010 (online)

Significance
Chiral lithium complexes are relatively less represented in asymmetric catalysis, although they are rather simple compounds. This paper described a highly stereoselective chiral lithium binaphtholate catalyzed Mannich-type reaction between various aromatic aldimines and 1,3-dicarbonyl compounds. It’s also a very efficient way to construct consecutive stereocenters in high stereoselectivities.