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Synfacts 2010(4): 0380-0380  
DOI: 10.1055/s-0029-1219491
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Tamiflu

Contributor(s): Philip Kocienski
H. Osato, I. L. Jones, A. Chen*, C. L. L. Chai*
Shionogi & Co., Ltd., Hyogo, Japan and Institute of Chemical and Engineering Sciences, Singapore
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Publikationsdatum:
22. März 2010 (online)

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Significance

This is the 27th synthesis of Tamiflu (oseltamivir phosphate), the most widely used ­antiviral drug for the treatment of influenzas. The starting material, d-ribose, is cheap (ca. $30/kg). The synthesis features the use of a ring-closing metathesis to generate the ring.