Synthesis of (S)-(+)-Dapoxetine

doi:10.1055/s-0029-1219486

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Synfacts 2010(4): 0388-0388
DOI: 10.1055/s-0029-1219486

Synthesis of Natural Products and Potential Drugs

Synthesis of (S)-(+)-Dapoxetine

Contributor(s): Philip Kocienski
S. Kang, H.-K. Lee*
Korea Research Institute of Chemical Technology, Daejeon and University of Science and Technology, Daejeon, Korea

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Publication History

Publication Date:
22 March 2010 (online)

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Significance

(S)-(+)-Dapoxetine (Priligy^®) is a potent selective serotonin reuptake inhibitor with a short half-life that is used to treat premature ejaculation. The key step in the asymmetric synthesis shown is an asymmetric C-H amination catalyzed by Rh₂(R-nap)₄.