Diastereoselective Negishi Coupling of Cycloalkylzinc Reagents

Significance

The use of sp^³-hybridized carbon nucleophiles is becoming more common in cross-coupling reactions. The authors present an sp^³-sp^² Negishi cross-coupling protocol that allows for the synthesis of disubstituted cyclohexanes with high diastereoselectivity. Substituents as small as a methyl group on the ring are sufficient to induce high selectivity.