Asymmetric Addition of Aromatic Nucleophiles to Isatins
N. V. Hanhan, A. H. Sahin, T. W. Chang, J. C. Fettinger, A. K. Franz*
University of California, Davis, USA
22 March 2010 (online)
This work outlines a Lewis acid catalyzed addition of unactivated electron-rich arene nucleophiles to isatins. A good scope of halogenated isatins is evaluated with generally good yields and ee values. While this reactivity of isatins with nucleophiles is known, this work focuses on the underreported addition of indoles and other heterocyclic nucleophiles.