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Synfacts 2010(4): 0386-0386  
DOI: 10.1055/s-0029-1219455
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Syntheses of (-)-Renieramycin M and G and (-)-Jorumycin

Contributor(s): Steven V. Ley, Catherine F. Carter
Y.-C. Wu, J. Zhu*
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
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Publikationsdatum:
22. März 2010 (online)

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Significance

All three of these bistetrahydroisoquinoline natural products possess potent anti­tumor antibiotic activities. They are all synthesized in appreciable overall yields starting from 2,6-dimethoxytoluene.