Syntheses of Isodomoic Acids G and H

doi:10.1055/s-0029-1219447

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Synfacts 2010(4): 0391-0391
DOI: 10.1055/s-0029-1219447

Synthesis of Natural Products and Potential Drugs

Syntheses of Isodomoic Acids G and H

Contributor(s): Steven V. Ley, Matthew O’Brien
S. E. Denmark*, J. H.-C. Liu, J. M. Muhuhi
University of Illinois, Urbana, USA

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Publikationsverlauf

Publikationsdatum:
22. März 2010 (online)

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Significance

Isodomoic acids G and H were isolated from the red algae Chondria armata and belong to the family of neuroexitatory kainoid amino acids which are important research tools in neuroscience and medicinal chemistry. Notable steps in the syntheses are a carbonylative silylcarbacyclization and a silicon-based sp^²-sp^² coupling.