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Synlett 2010(2): 335-336
DOI: 10.1055/s-0029-1219043
DOI: 10.1055/s-0029-1219043
SPOTLIGHT
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1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride (EDCI×HCl)
Further Information
Publication History
Publication Date:
08 January 2010 (online)
Introduction
1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI˙HCl) [¹] is a white crystalline solid with a melting point of 110-115 ˚C. EDCI˙HCl is a versatile organic reagent for many reactions. It is an effective dehydrating agent commonly used in the synthesis of amides, esters and anhydrides. [²] In these reactions, an acyl urea is a byproduct, which is water-soluble. This property of EDCI˙HCl makes it a very important chemical in its own class, superior to other traditional coupling reagents. It can also be used in the synthesis of oxazoles, oxadiazoles, triazoles, and guanidine compounds.
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