Synlett 2010(2): 335-336  
DOI: 10.1055/s-0029-1219043
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride (EDCI×HCl)

Navneet Goyal
Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA
e-Mail: ngoyal@uno.edu;
Further Information

Publication History

Publication Date:
08 January 2010 (online)

Introduction

1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI˙HCl) [¹] is a white crystalline solid with a melting point of 110-115 ˚C. EDCI˙HCl is a versatile organic reagent for many reactions. It is an effective dehydrating agent commonly used in the synthesis of amides, esters and anhydrides. [²] In these reactions, an acyl urea is a byproduct, which is water-soluble. This property of ­EDCI˙HCl makes it a very important chemical in its own class, superior to other traditional coupling reagents. It can also be used in the synthesis of oxazoles, oxadiazoles, triazoles, and guanidine compounds.

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