Mild Conditions for Copper-Catalyzed
N-Arylation of Imidazoles

Huaming Chen; Deping Wang; Xianyang Wang; Wenlong Huang; Qian Cai; Ke Ding

doi:10.1055/s-0029-1218691

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Synthesis 2010(9): 1505-1511
DOI: 10.1055/s-0029-1218691

PAPER

Mild Conditions for Copper-Catalyzed N-Arylation of Imidazoles

Huaming Chen^a, Deping Wang^b,c, Xianyang Wang^d, Wenlong Huang*^a, Qian Cai^b, Ke Ding*^b
^a China Pharmaceutical University, # 24 Tongjiaxiang, Nanjing 210009, P. R. of China
e-Mail: ydhuangwenlong@126.com;
^b Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou International Business Incubator D-10, Guangzhou Science Park, Guangzhou 510663, P. R. of China
Fax: +86(20)32290606.; e-Mail: ding_ke@gibh.ac.cn;
^c Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, 19AYuquan Road, Beijing 100049, P. R. of China
^d Jiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, 5 Xinmofan Road, Nanjing 210009, P. R. of China

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Publication History

Received 7 December 2009
Publication Date:
09 March 2010 (online)

Abstract
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Abstract

An efficient copper(I) bromide catalyzed N-arylation of azoles with a variety of aromatic bromides and iodides under mild conditions is reported. This reaction displayed great functional group compatibility and excellent reactive selectivity.

Key words

copper - aryl halides - imidazoles - azoles - N-arylation

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