Noncatalytic Electrophilic Oxyalkylation of 3-Aminopyrazoles with 2-(Trifluoroacetyl)-1,3-azoles
29 January 2010 (eFirst)
2-(Trifluoroacetyl)-1,3-azoles reacted with 3-aminopyrazoles to give the corresponding trifluoromethyl-substituted alcohols. The conditions required for the reaction and the yields of the products were highly dependent on the electronic nature of the both the 1,3-azole and the 3-aminopyrazole units.
heterocycles - alkylations - fluoro compounds - alcohols - aminopyrazoles