Synthesis 2010(7): 1200-1204  
DOI: 10.1055/s-0029-1218646
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Asymmetric Synthesis of 2,5-Naphthylpyrrolidine

Johannes F. Teichert, Ben L. Feringa*
Stratingh Institute for Chemistry and Center for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands
Fax: +31(50)3634296; e-Mail: b.l.feringa@rug.nl;
Further Information

Publication History

Received 2 December 2009
Publication Date:
12 January 2010 (eFirst)

Abstract

A novel, straightforward fully catalytic asymmetric synthesis of chiral 2,5-naphthylpyrrolidine based upon an iridium-catalyzed double allylic amination with ammonia has been developed. The products are available in high yields and enantioselectivities.