Catalytic Asymmetric Synthesis of 2,5-Naphthylpyrrolidine
12 January 2010 (eFirst)
A novel, straightforward fully catalytic asymmetric synthesis of chiral 2,5-naphthylpyrrolidine based upon an iridium-catalyzed double allylic amination with ammonia has been developed. The products are available in high yields and enantioselectivities.
asymmetric catalysis - enantioselectivity - heterocycles - transition metals - amination