A Direct, Copper-Catalyzed Functionalization of Pyridines with Alkynes
04 January 2010 (eFirst)
A one-pot, copper-catalyzed method to construct 2-alkynylpyridines is presented. This provides a route to access these products directly from terminal alkynes and the parent pyridine, and without prefunctionalization of the pyridine core. In addition, (Z)-alk-2-enylpyridines can be prepared via a related procedure. These reactions are used to synthesize a number of new alkynyl- and alkenyl-substituted pyridines in one pot.
pyridine - copper - catalytic - alkyne - alkene