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Synfacts 2009(10): 1063-1063  
DOI: 10.1055/s-0029-1217861
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Haouamine A

Contributor(s): Philip Kocienski, Indu Dager
T. Taniguchi, H. Zaimoku, H. Ishibashi*
Kanazawa University, Japan
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Haoumine A is isolated from the marine ascidian Aplidium haouarianum and shows strong anticancer activity in human colon carci­noma cell lines HT-29. This formal synthesis of ­haouamine A presents a concise route to Baran’s intermediate, the indenotetrahydropyridine K, ­using an intramolecular cascade Mizoroki-Heck reaction as a key step. For a total synthesis, see: J. Am. Chem. Soc. 2006, 128, 3908.