Synlett 2009(11): 1827-1829  
DOI: 10.1055/s-0029-1217355
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Trifluoromethyl-Substituted Analogues of 1-Aminocyclobutane-1-carboxylic Acid

Dmytro S. Radchenkoa,b, Pavel K. Mykhailiuk*a, Andrii V. Bezdudnyb,c, Igor V. Komarova,b
a Department of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street 64, 01033 Kiev, Ukraine
Fax: +380(44)2351273; e-Mail: pashamk@gmx.de;
b Enamine Ltd., Oleksandra Matrosova Street 23, 01103 Kiev, Ukraine
c The Institute of Organic Chemistry, The National Academy of Sciences of Ukraine, Murmanska Street 5, 02660 Kiev-94, Ukraine
Further Information

Publication History

Received 6 March 2009
Publication Date:
12 June 2009 (eFirst)

Abstract

Trifluoromethyl-substituted analogues of the 1-amino-cyclobutane-1-carboxylic acid - 1-amino-3-(trifluoromethyl) ­cyclo­butanecarboxylic and 1-amino-3,3-bis(trifluoromethyl)cyclobutanecarboxylic acids - have been synthesized from 1,3-dibromoacetone dimethyl ketal. The key step of the syntheses is a transformation of the acid moiety into the trifluoromethyl group using SF4 and HF.