Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate
13 May 2009 (eFirst)
A convenient approach for the synthesis of tetrasubstituted pyrazoles is described. The method involves the treatment of 1,3-diketones and allyltrimethylsilane with CAN followed by cerium-catalyzed addition of substituted hydrazines to construct pyrazoles in good yields.
heterocycles - pyrazoles - ceric ammonium nitrate - allylation - hydrazines