Synlett 2009(9): 1490-1494  
DOI: 10.1055/s-0029-1217163
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate

James J. Devery, III, Pramod K. Mohanta, Brian M. Casey, Robert A. Flowers, II*Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA
Fax: +1(610)7586536; e-Mail: rof2@lehigh.edu;
Further Information

Publication History

Received 7 January 2009
Publication Date:
13 May 2009 (eFirst)

Abstract

A convenient approach for the synthesis of tetrasubstituted pyrazoles is described. The method involves the treatment of 1,3-diketones and allyltrimethylsilane with CAN followed by cerium-catalyzed addition of substituted hydrazines to construct pyrazoles in good yields.