Synthesis of 2,2′-Bipyridines
via Suzuki-Miyaura Cross-Coupling

Christoph Gütz; Arne Lützen

doi:10.1055/s-0029-1217082

PAPER

Synthesis of 2,2′-Bipyridines via Suzuki-Miyaura Cross-Coupling

Christoph Gütz, Arne Lützen*
University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany
Fax: +49(228)739608; e-Mail: arne.luetzen@uni-bonn.de;

Abstract

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Abstract

For a long time, the Suzuki-Miyaura cross-coupling reaction could not be used for the synthesis of 2,2′-bipyridines due to the lack of sufficiently stable 2-pyridylboron compounds. Stabilized 2-pyridylboronic acid esters recently developed by Hodgson, however, were found to be ideally suited for this purpose. Two general protocols could be developed and demonstrated to be valuable alternatives, which can be used very efficiently for the synthesis of functionalized 2,2′-bipyridines.

Key words

cross-coupling reactions - bipyridines - palladium - 2-pyridylboronic acid esters - Suzuki-Miyaura reaction

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