Abstract
Glycosyltransferases and glycosidases work together to construct
the oligosaccharide moieties of biologically active glycoconjugates.
Although many excellent glycosidase inhibitors have been developed,
some of which are in clinical use, there are relatively few promising
candidates of glycosyltransferase inhibitors. In this review, we
summarize the current state of the development of glycosyltransferase
inhibitors.
1 Introduction
2 Basic Strategy for Designing Glycosyltransferase Inhibitors
3 Sugar Nucleotide Analogues
4 Analogues of Acceptor Oligosaccharides (Acceptor
Analogues)
5 Bisubstrate Inhibitors
6 High-Throughput Screening: Discovering Structurally
Simple
Inhibitors
7 Antisense Inhibitors
8 Questions and Future Directions
Key words
glycosyltransferases - inhibitors - transition-state
analogues - sugar nucleotides - oligosaccharides
