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Synthesis 2009(19): 3322-3326
DOI: 10.1055/s-0029-1216937
DOI: 10.1055/s-0029-1216937
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A New Access to 16-Membered Macrocycles: Synthesis of the Model C-O-D Ring System of Vancomycin
Further Information
Received
27 April 2009
Publication Date:
14 August 2009 (online)
Publication History
Publication Date:
14 August 2009 (online)
Abstract
A simple methodology for construction of the C-O-D diphenyl ether 16-membered ring system present in vancomycin by an intramolecular O-arylation reaction of arylboronic acid with substituted phenol for formation of the macrocyclic biaryl ether is described.
Key words
vancomycin - antibiotics - arylboronate - ring closure - O-arylation
- 1
Glycopeptide
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