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Synthesis 2009(12): 2035-2039  
DOI: 10.1055/s-0029-1216805
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Strecker-Type Reaction Catalyzed by Carboxylic Acids in Aqueous Media

Zhengfeng Xiea,b, Guilong Lic, Gang Zhao*c, Jide Wang*a,b
a School of Sciences, Xi’an Jiaotong University, Xi’an 710049, P. R. of China
b College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, P. R. of China
Fax: +86(991)8582807; e-Mail: awangjd@xju.edu.cn ;
c Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. of China
Fax: +86(21)64166128; e-Mail: Zhaog@mail.sioc.ac.cn;
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Publication History

Received 16 December 2008
Publication Date:
12 May 2009 (online)

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Abstract

Carboxylic acid catalyzed Strecker-type reactions were successfully carried out by simply mixing aldehydes, amines, tributyltin cyanide and carboxylic acid in aqueous media at room temperature, to afford α-aminonitriles in high yields.

Key words

Strecker reaction - α-aminonitriles - tributyltin cyanide - carboxylic acid - aqueous media