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Synthesis 2009(11): 1811-1814  
DOI: 10.1055/s-0029-1216791
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Thioflavanone and Flavanone Derivatives by Cyclization of Chalcones

Wojciech Konieczny*, Marek Konieczny
Department of Organic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk, Poland
Fax: +48(58)3493145; e-Mail: wkonieczny@amg.gda.pl;
Further Information

Publication History

Received 31 December 2008
Publication Date:
04 May 2009 (online)

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Abstract

Chalcones bearing suitably positioned protected 2′-sulfanyl or 6′-hydroxy groups cyclize to form the corresponding thioflavanones and flavanones, respectively. The thioflavanones were prepared by a new method involving deprotection of the sulfanyl group under alkaline conditions. These reactions provide a route to new biologically interesting molecules.

Key words

chalcone cyclization - thioflavanone synthesis - benz­oxathiolone ring opening - flavanones

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