Synlett 2009(8): 1241-1244  
DOI: 10.1055/s-0029-1216748
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of β-Trifluoromethylated Enones: An Unexpected Reactivity of Trifluoromethylated Weinreb Enamides towards Organolithium Species

Olivier Marrec, Julien Borrini, Thierry Billard*, Bernard R. Langlois
Université de Lyon, Université Lyon 1, CNRS, ICBMS, Laboratoire SERCOF, Bat Chevreul, 43 Boulevard du 11 Novembre 1918,69622 Lyon, France
Fax: +33(4)72431323; e-Mail: billard@univ-lyon1.fr;
Further Information

Publication History

Received 7 January 2009
Publication Date:
07 May 2009 (online)

Abstract

β-Trifluoromethylated enones can be synthesized in four steps from ethyl trifluoroacetoacetate. The key intermediate is a weinreb β-trifluoromethylated enamide.