Synthesis 2009(9): 1578-1581  
DOI: 10.1055/s-0028-1088026
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

Conversion of Primary Alcohols and Aldehydes into Methyl Esters by Ruthenium-Catalysed Hydrogen Transfer Reactions

Nathan A. Owstona, Tracy D. Nixona, Alexandra J. Parkerb, Michael K. Whittleseya, Jonathan M. J. Williams*a
a Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
Fax: +44(1225)386231; e-Mail: j.m.j.williams@bath.ac.uk;
b AstraZeneca, Global Process R&D, Avlon Works, Severn Road, Hallen, Bristol, BS10 7ZE, UK
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Publikationsverlauf

Received 5 December 2008
Publikationsdatum:
14. April 2009 (online)

Abstract

Alcohols and aldehydes are oxidised to the corresponding methyl esters by reaction with methanol in the presence of crotono­nitrile as a hydrogen acceptor using a catalyst combination of Ru(PPh3)3(CO)H2 with xantphos.