Synthesis 2009(8): 1400-1402  
DOI: 10.1055/s-0028-1088009
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Gram-Scale Synthesis of Highly Substituted Pyridine Derivatives

Kanniyappan Parthasarathy, Chien-Hong Cheng*
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan
Fax: +886(3)5724698; e-Mail: [email protected];
Further Information

Publication History

Received 15 November 2008
Publication Date:
06 March 2009 (online)

Abstract

Rhodium-catalyzed chelation-assisted activation of the β-C-H bond of α,β-unsaturated ketoximes and subsequent reaction with alkynes affords highly substituted pyridine derivatives. This new method provides an opportunity for the one-pot synthesis of pyridines with all five positions (C2-C6) substituted.

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