IBX/TBAB-Mediated Oxidation of Primary Amines to Nitriles
06 March 2009 (eFirst)
The combination of o-iodoxybenzoic acid (IBX) and tetrabutylammonium bromide (TBAB) efficiently oxidizes primary amines to the corresponding nitriles in good to excellent yield under mild conditions. The reaction is racemization-free when applied to a chiral lysine derivative.
o-iodoxybenzoic acid (IBX) - tetrabutylammonium bromide (TBAB) - amines - nitriles - oxidation - dehydrogenation