Synthetic Routes to Aminotriamantanes,
Topological Analogues of the Neuroprotector Memantine®

Andrey A. Fokin; Anika Merz; Natalie A. Fokina; Hartmut Schwertfeger; Shenggao L. Liu; Jeremy E. P. Dahl; Robert K. M. Carlson; Peter R. Schreiner

doi:10.1055/s-0028-1087979

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Synthesis 2009(6): 909-912
DOI: 10.1055/s-0028-1087979

PAPER

Synthetic Routes to Aminotriamantanes, Topological Analogues of the Neuroprotector Memantine^®

Andrey A. Fokin*^a,b, Anika Merz^b, Natalie A. Fokina^b, Hartmut Schwertfeger^b, Shenggao L. Liu^c, Jeremy E. P. Dahl^c, Robert K. M. Carlson^c, Peter R. Schreiner*^b
^a Department of Organic Chemistry, Kiev Polytechnic Institute, pr. Pobedy 37, 03056 Kiev, Ukraine
^b Institute of Organic Chemistry, Justus-Liebig University, Heinrich-Buff-Ring 58, 35392 Giessen, Germany
^c MolecularDiamond Technologies, Chevron Technology Ventures, 100 Chevron Way, Richmond, CA 94802, USA
Fax: +49(641)9934309; e-Mail: aaf@xtf.ntu-kpi.kiev.ua; e-Mail: prs@org.chemie.uni-giessen.de;

Further Information

Publication History

Received 22 September 2008
Publication Date:
02 March 2009 (online)

Abstract
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Abstract

The amino derivatives of diamantane and triamantane, representing close topological analogues of the neuroprotective drug Memantine®, were prepared via amination of the respective carboxylic acids or alcohols.

Key words

amines - diols - drugs - hydrocarbons - medicinal chemistry

References

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The structures have been deposited in the Cambridge Crystallographic Data Centre and can be retrieved using the following numbers: CCDC 701883 (14) and 701884 (16).