Synthesis of Cannabinoids
J. A. Teske, A. Deiters*
North Carolina State University, Raleigh, USA
20 November 2008 (online)
The psychotropic, antiemetic, analgesic, and anticonvulsant properties of Cannabis plants have been known since the third millennium BC. Cannabinoids target two cell receptors: the central cannabinoid receptor CB1 and the peripheral cannabinoid receptor CB2. A [2+2+2] cyclotrimerization reaction gave access to three different cannabinoid analogues from the same intermediate, providing a flexible synthetic route.