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Synthesis 2008(23): 3742-3744  
DOI: 10.1055/s-0028-1083637
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Reaction between 1,n-Diamines, Diketene, and Dibenzoylacetylene in the Presence of Triphenylphosphine: One-Pot, Pseudo-Five-Component Synthesis of Bisfuramides

Abdolali Alizadeh*, Reza Hosseinpour, Sadegh Rostamnia
Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran 18716, Iran
Fax: +98(21)88006544; e-Mail: abdol_alizad@yahoo.com; e-Mail: aalizadeh@modares.ac.ir;
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Publication History

Received 30 June 2008
Publication Date:
06 November 2008 (online)

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Abstract

Using diketene as a basic reagent, a one-pot, pseudo-five-component reaction for the synthesis of highly substituted bisfuramides is described. In this method, ring opening of diketene occurs in mild condition and without a catalyst. Thus, the reaction between diketene, 1,n-diamine, and dibenzoylacetylene, in the presence of triphenylphosphine, produces bisfuramides.

Keywords

diketene - dibenzoylacetylene - 1,n-diamine - triphenyl­phosphine - bisfuramide

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