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Synfacts 2008(12): 1311-1311  
DOI: 10.1055/s-0028-1083597
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cyclization of α-Amino Alkyllithium Reagents via Carbolithiation

Contributor(s): Paul Knochel, Andreas J. Wagner
R. J. Bahde, S. D. Rychnovsky*
University of California, Irvine, USA
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Publikationsverlauf

Publikationsdatum:
20. November 2008 (online)

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Significance

A new route to tertiary α-amino ­stereocenters by carbolithiation of alkylated ­aminonitriles is reported. The cyclic or spirocyclic products are obtained in satisfactory yields and moderate to high diastereoselectivities.