Synfacts 2008(12): 1318-1318  
DOI: 10.1055/s-0028-1083587
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Coupling of Cyclopropyl- and Cyclobutyl-trifluoroborates with Aryl Chlorides

Contributor(s): Paul Knochel, Andrei Gavryushin
G. A. Molander*, P. E. Gormisky
University of Pennsylvania, Philadelphia, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
20. November 2008 (online)

Significance

Specific steric and electronic properties of cyclopropyl and cyclobutyl groups give interesting opportunities for the creation of new biologically active molecules. This convenient and versatile method protocol uses cycloalkyltrifluoro­borates as shelf-stable cycloalkyl nucleophiles, and inexpensive aryl chlorides as coupling partners.