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Synfacts 2008(12): 1318-1318
DOI: 10.1055/s-0028-1083587
DOI: 10.1055/s-0028-1083587
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Coupling of Cyclopropyl- and Cyclobutyl-trifluoroborates with Aryl Chlorides
G. A. Molander*, P. E. Gormisky
University of Pennsylvania, Philadelphia, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2008 (online)

Significance
Specific steric and electronic properties of cyclopropyl and cyclobutyl groups give interesting opportunities for the creation of new biologically active molecules. This convenient and versatile method protocol uses cycloalkyltrifluoroborates as shelf-stable cycloalkyl nucleophiles, and inexpensive aryl chlorides as coupling partners.