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Synthesis 2009(4): 674-680  
DOI: 10.1055/s-0028-1083339
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Expedient Synthesis of Bis-Fused Benzofuran and a Two-Directional Ring-Closing Metathesis for the Synthesis of Bisbenzoxepines and Bisbenzoxocines

Krishna C. Majumdar*, Buddhadeb Chattopadhyay, Santanu Chakravorty
Department of Chemistry, University of Kalyani, Kalyani, West Bengal 741235, India
Fax: +91(33)25828282; e-Mail: kcm_ku@yahoo.co.in;
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Publication History

Received 25 September 2008
Publication Date:
27 January 2009 (online)

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Abstract

Synthesis of bis-fused benzofuran derivatives by the implementation of palladium-mediated intramolecular cyclization is described. To our knowledge, this is the first report of the synthesis of bis-fused benzofuran by this protocol. Bisbenzoxepine and bisbenzoxocine derivatives were also synthesized by the application of two-directional ring-closing metathesis.

Key words

palladium catalyst - Grubbs catalyst - intramolecular cyclization - two-directional ring-closing metathesis - 5-exo-trig - benzofuran - oxepine - oxocine

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