Abstract
A facile and efficient one-pot procedure for the preparation
of pyrazino[3′,2′:4,5]thieno[3,2-d ]pyrimidines following a tandem
aza-Wittig/electrocyclic ring closure strategy is described.
The one-pot, three-step reaction between 3-amino-2-formylthieno[2,3-b ]pyrazine, primary amines,
dichlorotriphenylphosphine and heterocumulenes, proceeded effectively
and the yields of the products were higher than in the stepwise
process. The products can also be prepared directly by a one-pot,
two-step reaction using the same aldehyde, dichlorotriphenylphosphine
and isocyanates. The advantages of the present method are easily
accessible starting materials, experimental simplicity of the one-pot
procedure, and good yields.
Key words
heterocycles - Wittig reaction - electrocyclic
reactions - phosphazenes - cyclizations
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