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Synthesis 2009(3): 502-507  
DOI: 10.1055/s-0028-1083294
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© Georg Thieme Verlag Stuttgart ˙ New York

2-Oxazol-5-ylethanones by Consecutive Three-Component Amidation-Coupling-Cycloisomerization (ACCI) Sequence

Eugen Merkul, Oliver Grotkopp, Thomas J. J. Müller*
Lehrstuhl für Organische Chemie, Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany
Fax: +49(211)8114324; e-Mail: ThomasJJ.Mueller@uni-duesseldorf.de;
Further Information

Publication History

Received 4 September 2008
Publication Date:
19 December 2008 (online)

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Abstract

Substituted oxazol-5-ylethanones can be synthesized in a consecutive three-component sequence starting from propargylamine and various acid chlorides, both for amidation and cross-coupling. Therefore, this diversity-oriented one-pot approach to substituted oxazoles can be considered as an amidation-coupling-cycloisomerization (ACCI) sequence.

Key words

C-C coupling - catalysis - cycloisomerization - multi-component reactions - oxazoles

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