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Synthesis 2008(21): 3433-3442  
DOI: 10.1055/s-0028-1083189
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthetic Studies towards the Development of Psoralen-Acidic Retinoid Conjugates and Hybrids

Maria Militsopoulou, Stavros E. Bariamis, Constantinos M. Athanassopoulos, Dionissios Papaioannou*
Laboratory of Synthetic Organic Chemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
Fax: +30(261)0997156; e-Mail: dapapaio@chemistry.upatras.gr;
Further Information

Publication History

Received 27 May 2008
Publication Date:
16 October 2008 (online)

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Abstract

The chemical modification of trioxsalen using electrophilic aromatic substitution reactions, followed by either Wittig or Heck reactions or Suzuki coupling, allowed for ready access to C4′ modified trioxsalen derivatives that were successfully used for the preparation of a variety of trioxsalen conjugates with acitretin of either the polyamine or the ester type and trioxsalen-acitretin hybrids.

Key words

electrophilic aromatic substitution - Heck reaction - psoralen-retinoid conjugation - Suzuki coupling - Wittig reaction

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