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Synthesis 2008(20): 3326-3330  
DOI: 10.1055/s-0028-1083143
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A General Procedure to Access Methylene Ether Isonitrile Derivatives

Rebecca L. Grangea, Craig M. Williams*a, Lin Donga, Victoria A. Gordonb
a School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Australia
Fax: +61(7)33654299; e-Mail: c.williams3@uq.edu.au;
b EcoBiotics Limited, PO Box 1, Yungaburra 4884, Australia
Further Information

Publication History

Received 29 April 2008
Publication Date:
25 September 2008 (online)

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Abstract

Isonitriles are essential building blocks for multicomponent reactions. A convenient and simple two-step synthesis of the little known methylene ether isonitrile derivatives is presented.

Key words

formamide - dehydration - isonitrile/isocyanide - multicomponent reactions

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