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Synlett
DOI: 10.1055/a-2774-1477
Letter

Electrochemical Synthesis of Pyrrolo[1,2-a]quinoxalines by Cyclization of 2-(1H-pyrrol-1-yl)anilines and Alcohols

Authors

  • Yingxue Ji

    1   School of Pharmacy, Shanxi Medical University, Taiyuan, China (Ringgold ID: RIN74648)

  • Wenxue Li

    2   Ministry of Education, Peptide & Protein Drug Research Center, Ningxia Medical University, Yinchuan, China (Ringgold ID: RIN105002)

  • Ye Zhang

    3   Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan, China (Ringgold ID: RIN105002)

  • Yinjun Wei

    2   Ministry of Education, Peptide & Protein Drug Research Center, Ningxia Medical University, Yinchuan, China (Ringgold ID: RIN105002)

  • Zhen Zheng

    4   Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Ringgold ID: RIN56694)

  • Fengkai Sun

    2   Ministry of Education, Peptide & Protein Drug Research Center, Ningxia Medical University, Yinchuan, China (Ringgold ID: RIN105002)

  • Zhenyu An 

    5   College of Pharmacy, Ningxia Medical University, Yinchuan, China (Ringgold ID: RIN105002)

  • Qian Li

    4   Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Ringgold ID: RIN56694)

  • Jian Zhang

    1   School of Pharmacy, Shanxi Medical University, Taiyuan, China (Ringgold ID: RIN74648)
    4   Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Ringgold ID: RIN56694)
    2   Ministry of Education, Peptide & Protein Drug Research Center, Ningxia Medical University, Yinchuan, China (Ringgold ID: RIN105002)

Supported by: Ningxia Natural Science Foundation Program 2023AAC03254
Supported by: Open Competition Mechanism to Select the Best Candidates for Key Research Projects of Ningxia Medical University XJKF240322
Supported by: Ningxia Peptide and Small Molecule Innovative Drug Research Science and Technology Innovation Team 2024CXTD013
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The electrochemical synthesis of pyrrolo[1,2-a]quinoxalines features the use of ethanol as both the reactant and solvent and a broad substrate scope, thus affording a wide range of 4methylpyrrolo[1,2-a]quinoxalines in moderate to good yields. Notably, for this efficient electrochemical synthesis protocol, neither metal catalysts nor exogenous additives/oxidants are required. Additionally, gram-scale reaction demonstrated the synthetic usefulness of this protocol.



Publication History

Received: 13 November 2025

Accepted after revision: 16 December 2025

Accepted Manuscript online:
16 December 2025

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