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Synthesis
DOI: 10.1055/a-2744-6345
Short Review

Biosynthesis and Synthesis of Griseoviridin and Viridogrisein

Authors

  • Leyan Xu

    1   Department of Chemistry, Rice University, Houston, United States (Ringgold ID: RIN3990)

  • Hans Renata

    2   Chemistry, Rice University, Houston, United States (Ringgold ID: RIN3990)

Supported by: National Institute of General Medical Sciences R35 GM128895
Further Information
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Griseoviridin and viridogrisein are synergistic type A/B streptogramin antibiotics that cooperatively inhibit protein translation in Gram-positive pathogens. This review provides an overview of their discovery and bioactivity and highlights key biosynthetic and synthetic advances that have enabled analog development to address antibiotic resistance. The review is organized into five sections: 1 Introduction 2 Structural assignment and biological studies 3 Biosynthesis 4 Synthesis 5 Conclusion



Publication History

Received: 04 September 2025

Accepted after revision: 11 November 2025

Accepted Manuscript online:
11 November 2025

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