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Synlett
DOI: 10.1055/a-2744-1923
Letter

Palladium-Catalysed C−H/N−H Annulations of (E,Z)-3-Arylidene Indolin-2-ones with Alkynes: A Synthesis of Benzazepine Derivatives

Authors

  • Kanniyappan Parthasarathy

    1   Organic Chemistry, University of Madras - Guindy Campus, Chennai, India (Ringgold ID: RIN164745)

  • Mohan Prabhakaran

    1   Organic Chemistry, University of Madras - Guindy Campus, Chennai, India (Ringgold ID: RIN164745)

Supported by: DST-SERB CRG/2021/001634
Supported by: New Delhi, India RUSA 2.0
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We developed an efficient palladium-catalyzed synthesis of benzazepine derivatives from (E,Z)-3-(arylidene)indolin-2-ones with alkynes, affording the desired products in good yields. The reaction proceeds via a palladium-catalyzed C-H/N-H activation, followed by alkyne insertion and reductive elimination sequences. Furthermore, we have also demonstrated the gram scale reaction as well as some synthetic transformations of the annulated products.Key words Benzazepines, (E,Z)-3-



Publication History

Received: 18 August 2025

Accepted after revision: 11 November 2025

Accepted Manuscript online:
11 November 2025

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