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Synthesis
DOI: 10.1055/a-2726-4234
Paper

Scalable and selective electrochemical benzylic C-H fluoroetherfication to fluorinated ethers

Autoren

  • yanyan Kong 

    1   School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, China

  • chao Wang

    2   School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, China (Ringgold ID: RIN34756)

  • xuemei Xu

    2   School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, China (Ringgold ID: RIN34756)

  • zekun Yang

    2   School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, China (Ringgold ID: RIN34756)

Gefördert durch: School foundation of Wuhan Institute of Technology K2023008
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lectrochemical dehydrogenative cross-coupling reaction has become a powerful strategy to construct C-O bond. However, electrochemically induced benzylic C-H fluoroetherfication still remains challenge due to the limitation of prefunctionalization, using metal-catalysts and chemical oxidants, multi-steps and narrow substrate scope. Herein, we present a green and efficient approach to synthesize diverse fluorinated ethers with ethylbenzenes and fluoroalcohols as substrates. This protocol exhibited good scalability. Mechanistic insights suggested that the radical might be involved in this reaction.



Publikationsverlauf

Eingereicht: 17. September 2025

Angenommen nach Revision: 17. Oktober 2025

Accepted Manuscript online:
17. Oktober 2025

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