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Synthesis
DOI: 10.1055/a-2723-2092
Paper

Cu(OAc)2/vasicine-catalyzed C-O coupling of 2-iodoanilides with MeOH

Authors

  • Wenxia Du

    1   School of Public Health, Kunming Medical University, Kunming, China (Ringgold ID: RIN71240)

  • Meiling Li

    2   Department of Pharmaceutics, Gejiu City Hospital of Integrated Traditional Chinese and Western Medicine, Gejiu, China

  • Jinlong Xie

    3   School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Ringgold ID: RIN177554)

  • WenHong Suo

    3   School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Ringgold ID: RIN177554)

  • Zewei Mao

    3   School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Ringgold ID: RIN177554)

  • Yun Sun 

    3   School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China (Ringgold ID: RIN177554)

Gefördert durch: Young and Middle-Aged Academic and Technological Leader of Yunnan 202405AC350042
Gefördert durch: Kuang Haixue Expert Workstation of Yunnan Province 202305AF150029
Gefördert durch: National Natural Science Foundation of China 82260830,82360842
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Preview

The metal-catalyzed functionalization of o-haloanilides has become a hot topic. In present work, we have explored a practical Cu/vasicine-catalyzed Ullmann-type C-O coupling methodology of 2-iodoanilides with MeOH, which could regioselectively form 2-methoxylanilides.



Publikationsverlauf

Eingereicht: 06. August 2025

Angenommen nach Revision: 14. Oktober 2025

Accepted Manuscript online:
14. Oktober 2025

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