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Synthesis
DOI: 10.1055/a-2722-9900
Paper

Iron-catalyzed One-Pot Four-Component Synthesis of Dihydropyridinones from Benzyl Alcohols and Ketones

Authors

  • Humaira Parveen 

    1   Department of Chemistry, University of Tabuk, Tabuk, Saudi Arabia (Ringgold ID: RIN125900)

  • Meshari A Alsharif

    2   Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia (Ringgold ID: RIN48058)

  • Mohammed Issa Alahmdi

    3   Department of chemistry, University of Tabuk, Tabuk, Saudi Arabia (Ringgold ID: RIN125900)

  • Omar M Alatawi

    1   Department of Chemistry, University of Tabuk, Tabuk, Saudi Arabia (Ringgold ID: RIN125900)

  • Mona O Albalawi

    1   Department of Chemistry, University of Tabuk, Tabuk, Saudi Arabia (Ringgold ID: RIN125900)

  • Sayeed Mukhtar

    4   Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia (Ringgold ID: RIN125900)

  • MOHD WAHEED 

    5   Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India (Ringgold ID: RIN30112)
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An efficient, facile and one-pot four-component methodology for the cyclization of readily available benzyl alcohols, acetophenones, Meldrum's acid and NH 4 OAc to access dihydropyridinones (valuable scaffolds in medicinal and synthetic organic chemistry) was established. This four-component cyclization reaction supports the straightforward manufacture of several dihydropyridinones. Several C-C and C-N bonds were constructs to synthesize the desired product. Readily available starting, operational simplicity, mild reaction conditions, good to excellent reaction yields, and tolerate various functional groups are the interesting features of this protocol.



Publication History

Received: 03 October 2025

Accepted: 14 October 2025

Accepted Manuscript online:
14 October 2025

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