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Synlett
DOI: 10.1055/a-2718-2019
Letter

Tungsten-Catalyzed Allylation of Sulfonyl Hydrazides: Regioselective Synthesis of Branched Allylic Sulfones

Authors

  • Wenbin Xu 

    1   Department of Chemistry, Jilin University of Chemical Technology, Jilin, China (Ringgold ID: RIN71106)

Supported by: Project of Jilin Education Department JJKH20220233KJ
Supported by: Jilin Institute of Chemical Technology 2021015,2021042
Supported by: Natural Science Foundation of Jilin Province YDZJ202201ZYTS348
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Highly regioselective tungsten (W)-catalyzed allylic sulfonylation of allylic carbonates with readily available sulfonyl hydrazides has been developed. Under tungsten catalysis, a variety of allylic sulfones can be delivered with the help of 4,4'-di-tert-butyl-2,2'bipyridine in moderate to good yields with excellent b/l regioselectivities. This approach features mild conditions, broad substrate scope, where aryl-and alkyl-substituted allylic carbonates and sulfonyl hydrazides are suitable substrates. This noble-metal-free catalyst system exhibits high reactivity and regioselectivity for the construction of C-S bond.



Publication History

Received: 13 September 2025

Accepted: 07 October 2025

Accepted Manuscript online:
07 October 2025

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