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Synthesis
DOI: 10.1055/a-2715-0392
Paper

Redox Coupling of Arylmagnesium Reagents with Gem-Dichloroalkanes Enables C(sp2)−C(sp3)/C(sp3)−C(sp3) Bond Formations

Authors

  • Rong Chen

    1   College of Chemistry and Chemical Engineering, Central South University, Changsha, China (Ringgold ID: RIN12570)

  • Wenhua Yu

    1   College of Chemistry and Chemical Engineering, Central South University, Changsha, China (Ringgold ID: RIN12570)

  • Shaopeng Wei

    1   College of Chemistry and Chemical Engineering, Central South University, Changsha, China (Ringgold ID: RIN12570)

  • Feng Ouyang

    1   College of Chemistry and Chemical Engineering, Central South University, Changsha, China (Ringgold ID: RIN12570)

  • Guipeng Yu

    1   College of Chemistry and Chemical Engineering, Central South University, Changsha, China (Ringgold ID: RIN12570)

  • Baosheng Wei 

    1   College of Chemistry and Chemical Engineering, Central South University, Changsha, China (Ringgold ID: RIN12570)
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The oxidative homocoupling of organomagnesium reagents has been well studied, but the sacrificial oxidants used in these reactions are usually not incorporated into the coupling products. Herein, we report a chromium or manganese-catalyzed coupling reaction of arylmagnesium reagents with gem-dichloroalkanes (RR’CCl2), in which RR’CCl2 serves as both oxidant and coupling reagent. This catalytic redox coupling reaction enables the convenient synthesis of various functionalized dibenzyl derivatives via successive C(sp2)−C(sp3)/C(sp3)−C(sp3) bond formations. A radical-involved mechanism is proposed and experimentally evidenced.



Publication History

Received: 31 August 2025

Accepted after revision: 01 October 2025

Accepted Manuscript online:
01 October 2025

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