Hydroformylation of Protected Propargylic Alcohols

Abstract

A rhodium catalyst modified with a self-assembling pyridone-based phosphine ligand enables a chemoselective hydroformylation of protected propargylic alcohols to furnish either 4-siloxy enals or protected 4-hydroxy aldehydes depending on the reaction conditions.

Keywords

Hydroformylation - Alkynes, Rhodium Catalysis - Propargylic Alcohols - Self-assembling Ligands, Enals - Silylethers

Publication History

Received: 03 July 2025

Accepted after revision: 28 August 2025

Article published online:
18 September 2025

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