Asymmetric Gold-catalyzed Alkyne Transformations for Synthesis of Axial, Helical, and Planar Chirality

Guan-Zhi Liu; Xin Nie; Long Li

doi:10.1055/a-2685-9147

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Synthesis
DOI: 10.1055/a-2685-9147

Short Review

Asymmetric Gold-catalyzed Alkyne Transformations for Synthesis of Axial, Helical, and Planar Chirality

Guan-Zhi Liu

¹College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, China (Ringgold ID: RIN26495)

,

Xin Nie

²College of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing, China (Ringgold ID: RIN372299)

,

Long Li

³College of Chemistry &Materials Engineering, Wenzhou University, Wenzhou, China (Ringgold ID: RIN26495)

› Author Affiliations
Supported by: Zhejiang Provincial Natural Science Foundation of China LQ23B020002
Supported by: National Natural Science Foundation of China 22401218

› Further Information

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Gold-catalyzed asymmetric alkyne transformations have emerged as a powerful strategy for constructing chiral architectures due to gold's unique carbophilic π-acidity. This review comprehensively summarizes recent breakthroughs in constructing non-central chirality, focusing on axial, helical, and planar chiral scaffolds. Beyond that, innovative ligand design and the underlying structure-activity relationships that govern stereocontrol are highlighted in this review. This overview provides insights into current trends in gold-catalyzed asymmetric synthesis.

Publication History

Received: 03 July 2025

Accepted after revision: 18 August 2025

Accepted Manuscript online:
18 August 2025

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