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Synthesis
DOI: 10.1055/a-2685-9147
DOI: 10.1055/a-2685-9147
Short Review
Asymmetric Gold-Catalyzed Alkyne Transformations for Synthesis of Axial, Helical, and Planar Chirality
Authors
Supported by: Zhejiang Provincial Natural Science Foundation of China LQ23B020002
We are grateful for financial support from the National Natural Science Foundation of China (22401218) and Zhejiang Provincial Natural Science Foundation of China (LQ23B020002).
Abstract
Gold-catalyzed asymmetric alkyne transformations have emerged as a powerful strategy for constructing chiral architectures owing to gold’s unique carbophilic π-acidity. This review comprehensively summarizes recent breakthroughs in constructing noncentral chirality, focusing on axial, helical, and planar chiral scaffolds. Beyond that, innovative ligand design and the underlying structure–activity relationships that govern stereocontrol are highlighted in this review. This overview provides insights into current trends in gold-catalyzed asymmetric synthesis.
Publication History
Received: 03 July 2025
Accepted after revision: 18 August 2025
Accepted Manuscript online:
18 August 2025
Article published online:
09 September 2025
© 2025. Thieme. All rights reserved.
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For recent selected reviews on the gold-catalyzed alkyne transformations:
For recent selected reviews on gold-catalyzed enantioselective synthesis of central chirality, see:
For recent selected reviews on axial chirality, see:
For recent selected works on axial chirality, see:
For recent selected reviews on application of helicene, see:
For recent selected works on axial chirality, see:
For recent selected reviews on planar chirality, see:
For recent selected works on axial chirality, see:
For recent selected reviews on central-to-axial chirality conversion strategy, see:
For selected examples of diastereoisomer resolution of racemic helicenes, see:
For selected examples of synthesizing helicenes through chiral auxiliaries, see:
For selected examples of nickel-catalyzed enantioselective synthesis of helicenes, see:
For selected examples of rhodium-catalyzed enantioselective synthesis of helicenes, see:
For selected examples of palladium-catalyzed enantioselective synthesis of helicenes, see: