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Synthesis
DOI: 10.1055/a-2685-9083
Paper

Desaturation of Amides via Bismuth Photocatalysis

Byeongdo Roh
1   Organometallic Chemistry, Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany (Ringgold ID: RIN28314)
,
Josep Cornella 
1   Organometallic Chemistry, Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany (Ringgold ID: RIN28314)
› Institutsangaben
Gefördert durch: Verband der Chemischen Industrie
Gefördert durch: Max-Planck-Gesellschaft
Gefördert durch: Novartis Early Career Award Foundation
Gefördert durch: Deutsche Forschungsgemeinschaft EXC 2033–390677874 –RESOLV
Gefördert durch: Max-Planck-Institut für Kohlenforschung
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Bismuth redox catalysis has been intensively developed in recent years, enabling diverse transformations that were previously thought to be achievable only through transition metal catalysis. In this study, we present the desaturation of amides to generate enamides, an important structural motif in pharmaceuticals, via bismuth photocatalysis. The protocol involves a combination of unique mechanistic steps recently uncovered for bismuth thus allowing for the translation of a canonical transition metal-mediated transformation into a main-group-based catalytic system.



Publikationsverlauf

Eingereicht: 23. Juni 2025

Angenommen nach Revision: 18. August 2025

Accepted Manuscript online:
18. August 2025

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