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Synthesis
DOI: 10.1055/a-2638-5962
paper

Palladium/Copper Co-catalyzed ipso-Alkynylation and ortho-Alkylation of Aryl Halides

Yijun Shi
1   College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, Zaozhuang, China (Ringgold ID: RIN372543)
,
Xuejing Liu
1   College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, Zaozhuang, China (Ringgold ID: RIN372543)
,
Chengwei Liu
2   Department of Chemistry, Shanghai University, Shanghai, China (Ringgold ID: RIN34747)
› Author Affiliations
Supported by: Zaozhuang University
Supported by: Overseas High-Level Talents Introduction Program of Shanghai
Supported by: Shanghai University
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A palladium/copper co-catalyzed ipso-alkynylation and ortho-alkylation has been reported. Aromatic halides, including aryl iodides and aryl bromides, can be used as substrates in this reaction. Furthermore, alkyl halides, including alkyl iodides, alkyl bromides, and alkyl chlorides, can be used as alkylation reagents for this approach. Broad substrate scope and excellent functional group tolerance of this platform has been demonstrated in the highly selective ipso-alkynylation and ortho-alkylation. The desired reactions were operated under mild and operationally-practical conditions providing a powerful approach for functionalizing of aryl halides.



Publication History

Received: 21 January 2025

Accepted after revision: 17 June 2025

Accepted Manuscript online:
17 June 2025

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