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Synthesis
DOI: 10.1055/a-2630-0589
short review

Enantioselective Copper-Catalyzed Allylic/Propargylic Acyloxylation: Asymmetric Variants of the Kharasch–Sosnovsky Reaction

Sheng Tang
1   State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China (Ringgold ID: RIN12581)
,
Shouyun Yu 
1   State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China (Ringgold ID: RIN12581)
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Supported by: National Natural Science Foundation of China 22371119
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Copper-catalyzed enantioselective allylic/propargylic acyloxylation, evolving from the classical Kharasch-Sosnovsky reaction, has emerged as a versatile strategy for the stereocontrolled synthesis of chiral esters. This short review comprehensively summarizes recent advances in asymmetric variants of Kharasch-Sosnovsky reaction across three primary substrate categories: cyclic olefins, acyclic alkenes/alkynes, and 1,3-dienes/enynes, with particular emphasis on substrate scope and mechanistic insights.



Publication History

Received: 08 May 2025

Accepted after revision: 06 June 2025

Accepted Manuscript online:
06 June 2025

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