Lewis Acid-Catalyzed Cyanomethylation of α,β-Unsaturated Keto Esters and Activated Ketones Using Vinyl Azide as an Acetonitrile Equivalent

Abstract

Lewis acid-catalyzed cyanomethylation reactions of α,β-unsaturated ketoesters and ketoamides with α-isopropanol vinyl azide were reported. The corresponding cyanoalkylated products were obtained in 40–97% and 45–96% yields, respectively, through 1,4- and 1,2-addition pathways.

Keywords

Cyanomethylation reaction - Ketoester - Ketoamide - Vinyl azide

Publikationsverlauf

Eingereicht: 08. Mai 2025

Angenommen nach Revision: 04. Juni 2025

Accepted Manuscript online:
04. Juni 2025

Artikel online veröffentlicht:
24. Juli 2025

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