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Synlett
DOI: 10.1055/a-2626-0265
letter

A Straightforward Access to Specific Bisindole Systems Related to Fascaplysin Alkaloids

Liang Chen
1   State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China (Ringgold ID: RIN74628)
,
Zizhen Wang
1   State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China (Ringgold ID: RIN74628)
,
Yan Li
1   State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China (Ringgold ID: RIN74628)
2   -, Natural Products Research Center of Guizhou Province, Guiyang, China (Ringgold ID: RIN602519)
,
Sheng Liu 
1   State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, China (Ringgold ID: RIN74628)
2   -, Natural Products Research Center of Guizhou Province, Guiyang, China (Ringgold ID: RIN602519)
› Author Affiliations
Supported by: Natural Science Foundation of Guizhou Province QKH-ZC[2023]YB209 and QKH-ZC[2022]YB192.
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Reported here is a straightforward synthetic approach to the specific pentacyclic bisindole structures related to fascaplysin alkaloids. The key transformation is an acid-promoted cascade involving a C-N bond formation/Mannich-type cyclization/dehydrogenation sequence. 19 novel bisindole derivatives bearing a wide range of functional groups were prepared by this method.



Publication History

Received: 01 May 2025

Accepted after revision: 02 June 2025

Accepted Manuscript online:
02 June 2025

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